The headline on the press release says, “More Than Half of Texas Physicians Do Not Always Recommend HPV Vaccine to Girls.” That sounds bad.
The “sub headline” in the press release says, “Approximately 50 percent do not recommend the vaccine.” That sounds really bad.
The problem is that the headline is misleading and the “sub headline” isn’t true.
When you read the actual research paper, you find out that 75-87% of the doctors are making the right recommendation most of the time.
Given the strong social and political interest in this topic, those differences have significant implications, especially given the headline and sound bite world we live in today. And that could influence how this paper may be used to drive public policy.
First, a bit of background:
We know that the majority of cervical cancers in the
A cervical cancer vaccine was introduced in the
The reason for the young age is that the vaccine is not effective once a girl becomes sexually active. Additional recommendations, including those from the American Cancer Society, include offering the vaccine for girls as early as 9 years old, and as a “catch-up” for girls ages 13-18. The Society also recommends a discussion between a woman and her health care professional about cervical cancer vaccination if she is between the ages of 19-26.
The current report appears in the August issue of the journal Cancer Epidemiology Biomarkers and Prevention.
The researchers had three primary questions they wanted to answer with their study:
First, they wanted to find out whether or not physicians were recommending cervical cancer vaccination to 11 and 12 year old girls. Second, they wanted to know if physicians would recommend the same vaccine to 11 and 12 year old boys if it became available, understanding that studies have shown the same vaccine now used in girls will also reduce genital infections with HPV in boys. Finally, the researchers wanted to know if physicians agreed that HPV vaccination in 11-12 year old girls should be mandatory.
The study was conducted in
The researchers conducted an email survey to answer the questions they had posed above.
Focusing on just the physician recommendations to vaccinate 11 and 12 year old girls, the study concluded, “Half of the physicians in this study did not follow current recommendations for universal HPV vaccination of 11-to-12 year-old girls.”
Doesn’t sound too good, does it?
But wait a moment. In a graph in the paper, it says that 75.4 of the doctors “always/usually recommend vaccine to girls” in the primary target population of 11-12 years old. If you look at the same number for girls ages 13-17, the percentage actually climbs to 87.5%.
As a physician who has been in practice, and as someone who is very interested in the need to get doctors to recommend appropriate cancer screening tests to patients, that number actually sounds pretty good. In fact, I think it would be very difficult to get much better than that, especially in the 13-17 year old category.
Essentially, the headline all depends on whether you think there is much practical difference between “always” and “usually.” Frequently, researchers combine those categories into a single number because of the practical implications. Indeed, in their own graphical presentation of the data, the researchers in this paper combined the data. It’s when they wrote the conclusions that they elected to highlight that differences.
And that “sub headline” which says that approximately 50% of the physicians in
Using this information, the authors conclude that “additional efforts are needed to improve clinicians’ awareness of and adherence to national recommendations.”
The study also noted that the most effective way to get these girls vaccinated is to mandate the vaccine. “State vaccination requirements that would ensure high uptake of HPV vaccines also have the potential to narrow existing racial, ethnic, and economic disparities in cervical cancer incidence and mortality…(More than) 40% of Texas physicians in this 2008 study supported mandatory HPV vaccination.”
The authors do point out that there are several barriers to vaccination, including costs and misperceptions of safety and effectiveness—as well as personal parental beliefs—that may impact the rate of vaccination. But they also imply that doctors aren’t doing their job as well as they should.
I simply don’t agree that the data on its face supports that conclusion, and I don’t agree that the data necessarily reflect the opinions and/or practices of physicians across the country. When I dug deeper into the study, I found I had questions about how representative the sample was of all practicing physicians, not to mention questions about how many internists and gynecologists actually treat 11 to 12 year old girls in their practices. I also thought the study was (unintentionally) biased towards younger physicians whose opinions may not reflect the larger (and older) primary care physician workforce.
Some final items:
I want to make it clear that in my opinion this vaccine is useful in preventing cervical cancer. I have no personal opinion (nor does the American Cancer Society) as to whether or not the vaccine should be mandatory. The Society does recommend routine vaccination of girls 11-12 years old.
As I mentioned to a reporter during an interview yesterday, I believe that readers of this blog should be aware of potential conflicts of interest when I write about particular research reports.
In this case, one of the senior authors on the paper lists the following conflicts:
She is a co-Principal investigator on an investigator-initiated grant funded by the company that currently is the sole supplier of the cervical cancer vaccine in the
I would add that the study was funded by the Texas Medical Association Foundation. I applaud them for supporting this research, as well as their efforts to vaccinate children in areas of the state with low vaccination rates.
I could not find any indication that the company which makes the vaccine directly or indirectly supported this research, or made some type of grant which helped get the study completed.
The key “take away” message for me is that this particular study is a case example of how one can get attention by emphasizing the problem, as opposed to applauding the success. In my personal opinion, it shows how you can tilt the impact of a scientific paper depending on the message you want to send and the headlines (and sub headlines) that you write.
To sum it all up, whether you think this glass is half empty or half full may just depend on your point of view.